DIAGNOSTIC VALUE OF ADAMTS-7 IN JOINT DISEASES

Feruza Iskandarovna Khalmetova; Khalmurad Sadullayevich Akhmedov; Murodjon Arapbayevich Artikbayev

Authors

Feruza Iskandarovna Khalmetova Dsc, Tashkent Medical Academy, Tashkent, Uzbekistan
Khalmurad Sadullayevich Akhmedov Professor, Doctor of Medical Sciences, Tashkent Medical Academy
Murodjon Arapbayevich Artikbayev MD, "IMPULS BSR" Impuls Medical Institute

Keywords:

ADAMTS-7, reactive arthritis, joints syndrome.

Abstract

Reactive arthritis (RеА) is a "sterile" inflammatory joint disease in which infectious agents and their antigens are absent in the synovial fluid and synovial membrane of patients. RеА is a seronegative spondyloarthritis, which meets the criteria of the European Group for the Study of Spondyloarthritis. With the introduction into clinical practice in the early 90s of the reverse transcriptase polymerase chain reaction (RT–PCR) method, small amounts of Ch.trachomatis DNA and RNA were found in the joint cavity. The presence of these nucleic acids, which have a very short lifetime in tissues (several minutes), indicated the possibility of transcription and, consequently, active reproduction of bacteria in the joint cavity.